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Nakabayashi H, Nishizawa M, Nakagawa A, Takeda R, Niijima A

Increasing water intake to 2.53 liters daily, eating soft-cooked vegetables and prunes, and taking a daily magnesium supplement usually resolve constipation within 23 weeks

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This method bypasses the gastrointestinal tract and first-pass metabolism in the liver, potentially allowing for faster absorption and onset of action