In a recent work by Charbord et al., a novel method using a luminescence ubiquitination-based cell cycle indicator (LUCCI) in zebrafish was employed to discover HG-991-01 as a driver for cellular proliferation, which was subsequently verified in both mouse and human beta cells (Wagner 2022
However, it is noteworthy that genetic inhibition of IGF-1 and IGF-1R signaling has also shown beneficial effects in AD models [219]
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