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Of the 846 ligand-regulated phosphosites (categories I and II), 49 sites were equally upregulated (category I-A) and 288 sites were equally downregulated (category II-A) in both WT-IR and L973F-IR cells in response to ligand stimulation (up- or downregulation of these sites was not significantly changed between these 2 cell lines)

However, further research is needed to evaluate the potential benefits of antioxidants in this condition [226,227]