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Runx2/Osterix pathway: Upregulation of Runx2 (osteogenic differentiation core transcription factor) and Osterix expression induces directed differentiation of bone marrow mesenchymal stem cells into osteoblasts and increases new bone formation

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In vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy

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This individualized approach allows ALA therapy to contribute to more stable long-term outcomes