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2 People with this genotype have lower MTHFR activity, higher homocysteine levels, and a higher risk of cardiovascular and neurological diseases

Bennett BJ, de Aguiar Vallim TQ, Wang Z, et al

Across the entire orforglipron clinical development program, no hepatic safety signal has been identified

PlexusDx encourages patients to report storage incidents and consistency concerns to their healthcare provider

They may be used in conjunction with cardiovascular risk estimators and other risk factors and biomarkers to improve preventive care for those without known heart disease

While strict inclusion criteria ensured methodological quality, they may have reduced the breadth of eligible evidence, limiting the scope of subgroup analyses and the generalizability of certain findings