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Mannino GC, Greco A, De Lorenzo C, Andreozzi F, Marini MA, Perticone F, Sesti G

Fumarate, or fumaric acid, is a naturally occurring organic acid that serves as a direct intermediate in the Krebs cycle (also known as the Citric Acid Cycle or TCA cycle)

A rich source of antioxidants

Studies in Kuwait and Saudi Arabia found opposite results in children with autism

It is contraindicated in patients with certain mitochondrial disorders, porphyria, or fatty acid oxidation deficits

d , Oxygen consumption of primary mouse hepatocytes shown as the percentage of total respiration that is driven by the oxidation of indicated substrates (n=2 biologically independent samples/group)