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For a closer look at why this matters, our article on Is Liposomal Glutathione Absorbed

The E627* change results in a premature stop codon at the second helicase of the MDA5 protein

doi: 10.3389/fmicb.2020.562048 53 WuJMOraeeADoonanBBPintoJTHsiehTC

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These enzymes form a multienzyme metabolic complex, which translocates to the nucleus during S (DNA replication) and G2/M (DNA damage checkpoint) phases, and is required for biosynthesis of the nucleotide precursor, thymidylate, which is critical to DNA synthesis and repair

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