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Kagan, H

13 The objectives of this study are twofold: (1) to evaluate the extent to which semaglutide use is associated with a reduced risk of complications and (2) to compare these associations between patients using semaglutide and those who are not

Eli Lilly manufactures tirzepatide (Zepbound for weight loss, Mounjaro for diabetes), a dual GIP/GLP-1 receptor agonist showing superior weight loss compared to semaglutide monotherapy in head-to-head trials

Patients should stop the medication and contact their healthcare provider immediately if they experience: Severe or persistent abdominal pain (especially if radiating to the back), which could indicate pancreatitis Persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Yellowing of skin or eyes (jaundice) or pale stools Unexplained fever Severe diarrhoea lasting more than 48 hours Treatment continuation is reviewed regularly, with decisions based on efficacy, tolerability, and ongoing clinical need

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