Characterised by Francis and colleagues in the Journal of Molecular Endocrinology in 1992
NRF2 is a crucial regulatory factor that maintains intracellular redox homeostasis
While epidemiological evidence indicates that this motor system disease is associated with poisoning from cyanogenic glucosides found in improperly processed cassava, not all individuals who rely on a cyanogenic diet are affected during outbreaks of konzo, suggesting additional and yet unknown factors required for onset of disease 4,5
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Heavy metal detoxification requires patience and consistency
70,74 Patient-derived glioblastoma specimens exhibit overexpression of CDO1 and consequent accumulation of CSA