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Lipoic acid is an essential cofactor for the E2 component of -ketoacid dehydrogenase complexes that are exclusively located in mitochondria

10.3389/fimmu.2021.734229 16 CarvalhoA

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B Vitamins: The Behind-the-Scenes Crew B vitaminsespecially riboflavin (B2) and pyridoxine (B6)act as co-factors that help regenerate and recirculate glutathione

On the other hand, GGT might also exert a direct local pro-oxidant action contributing to plaque instability, rupture, and thrombosis and related clinical events