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Subsequently, glutamate dehydrogenase 1 (GLUD1) or multiple mitochondrial transaminases, such as alanine aminotransferase 2 (GPT2) and aspartate aminotransferase 2 (GOT2), convert mitochondrial glutamate to -KG (Fig

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Furthermore, fasting induces a metabolic shift from glucose to ketone utilization, providing neurons with a potent energy source that reduces mitochondrial stress and enhances bioenergetic stability [76]