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Derived from a sequence found in human gastric juice, it has been extensively studied in preclinical models for its effects on tissue repair, angiogenesis, and cellular regeneration

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Exendin-4 may affect -cell number by stimulating cellular proliferation 21, 22

It has been found, using specific knock out (KO) mice and cultures, different specific activities for IRS-1 and IRS-2, additional further complexity comes with tissue-specific roles

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