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More advanced deficiency produces balance problems, weakness in the legs, a sore and inflamed tongue (glossitis), and in severe cases, megaloblastic anemia where red blood cells become abnormally large and inefficient at carrying oxygen

8,17,132-137 Given that ME/CFS symptoms recur in some improved patients who discontinue therapies, suggesting suboptimal clearance of the underlying pathology, there is increasing speculation that combinations may be more efficacious than single treatments

[Google Scholar] 175.Sargeant JA, Henson J, King JA, Yates T, Khunti K, Davies MJ

There is no known direct drug-to-drug interaction where one medication makes the other toxic or completely ineffective

2020 Jan 6;: PMID: 31561944

Studies have also looked at berberine's potential health benefits and effectiveness in treating type 2 diabetes , high cholesterol , cardiovascular disease in men, and polycystic ovary syndrome (PCOS)