In mice, exenatide and semaglutide reduce plasma TNF- levels induced by agonists for TLR1, TLR2, TLR4, TLR5, and TLR9 or by cecal slurryinduced polymicrobial sepsis (22)
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The number needed to treat was 19, meaning that for every 19 patients treated with dapagliflozin, one major kidney event was prevented
And year-to-date in 2026, they're still ahead by 12 points