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There are no detectable GLP-1r on the liver or on skeletal muscle and yet GLP-1 has repeatedly been shown to not just increase insulin secretion but also to improve insulin sensitivity

Semaglutide stimulates insulin secretion from the pancreas when blood glucose levels are elevated, helping to lower blood sugar after meals

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Side-effect profiles The most common side effects for both medicines are gastrointestinal, including nausea, vomiting, and diarrhoea