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A recent analysis of the World Health Organizations pharmacovigilance database, VigiBase, found that there was an increased risk of suicidal ideation for patients taking semaglutide, liraglutide, and tirzepatide (Mounjaro, Zepbound) as compared with other medications for diabetes

But Wegovy may increase the risk of pancreatitis, gallbladder disease, severe gastrointestinal side effects that may lead to dehydration or kidney injury, increased heart rate, and suicidal thoughts or behaviors

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SOURCE: Annals of Internal Medicine , March 31, 2025 Copyright 2025 HealthDay

PMID: 33911742

GLP-1 receptor agonists also exert antioxidant, anti-inflammatory, and antifibrotic effects by downregulating pro-inflammatory pathways (e.g., nuclear factor-B), cytokines (e.g., transforming growth factor ), and T-cell proliferation [18]