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When the levels of these cytotoxic agents increase, serious damage occurs through the oxidative modification of macromolecules such as lipids, proteins, and DNA, and this process occurs more frequently with age

Relative contraindications include recurrent pancreatitis, gastroparesis, or ongoing unexplained gastrointestinal symptoms

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Semaglutide is primarily metabolized through proteolytic cleavage (protein breakdown) and beta-oxidation of the fatty acid side chain

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