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In contrast, iTregs arise in the periphery, where cytokines such as TGF- and IL-2 promote their antigen-induced Foxp3 expression and suppressive function, thereby establishing tolerance to foreign antigens
B12 has also been shown to bind with neurotransmitters such as dopamine and serotonin
1999 Oct;87(4):1381-5
As a result, vitamin B 12 deficiency is relatively common, especially among older people