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By the time it gets to where it is needed, it is no longer the "master antioxidant" it was supposed to be

The results showed that early administration of metformin was associated with a significant increase in height in 15-year-old children (Ibanez et al., 2011)

In early PD patients, a decrease in fractional anisotropy is commonly observed in the SN region (especially the SNpc), often accompanied by an increase in mean diffusivity or both (218, 219)