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GLP-1 medications like Ozempic, Wegovy, Zepbound, and Mounjaro are being hailed as breakthrough treatments, reshaping how Americans think about managing weight and metabolic health

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Semaglutide is a once-weekly GLP-1 injection

A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)

[DOI] [PubMed] [Google Scholar] 10.Chiasson J.L., Josse R.G., Gomis R., Hanefeld M., Karasik A., Laakso M., STOP-NIDDM Trial Research Group Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: The STOP-NIDDM trial

The science is still very thin