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Even when raw materials are present, the system works sluggishly, like an engine running on low oil
Exogenous factors, including various pollutants, could further increase extracellular GSSG, perhaps limiting the export of GSSG against a concentration gradient
(2017) CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF4 pathway, Oncotarget , 8 , 114588-114602, doi: Lei, P., Bai, T., and Sun, Y
As a result, these agents act together to cause additional oxidative damage, creating a never-ending chain reaction (also may be considered a feed-forward loop)
S C K wrote the manuscript with support and input from R A A and S M d S
Trends Neurosci 27 : 370377
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