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This triple effect is what allows it to produce larger average weight loss than single or dual hormone medications in clinical research

Early-phase data have suggested potential benefits in conditions such as hepatic steatosis (fatty liver disease) and dyslipidaemia, which frequently accompany obesity

Most patients maintain their weight loss on 5 to 10 mg of tirzepatide weekly after reaching their target

The 12 to 24 month wait for approval means this option suits only certain candidates

Ketamine and esketamine added a second mechanism class in 2019