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doi: 10.1007/s10753-013-9616-0 188 AhmedSRiegseckerSBeamerMRahmanABelliniJVBhansaliPet al
Five trials focused on participants with cardiovascular disease or risk factors, three trials included participants with cardiovascular disease alone, one trial enrolled those with cardiovascular or kidney disease and additional risk factors, and one included participants regardless of cardiovascular history
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The same calorie deficit that produced results in month two produces less in month six because your body needs fewer calories to maintain its new weight
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