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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
Normal liver enzymes do not rule out gallstones
Moreover, existing data indicate that single-target GLP-1RAs such as SEMA and liraglutide show promising capabilities for fibrosis improvement, and the initial success of the dual agonist tirzepatide suggests potential benefits of dose titration therapy in the monotherapy management of MASLD
This includes attenuating the amplification effect of hyperinsulinemia on the ovaries, reducing lipotoxic and inflammatory loads, and potentially creating a more favorable endometrial metabolic microenvironment
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