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Network dysfunction in the prefrontal cortex and limbic system, including the hippocampus and amygdala, has also been theorized as a potential cause of depressive disorders

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It has recently been shown that binding of lipid by CD36 upregulates apo B48 and MTP through CD36 signalling via the ERK-1/ERK-2 pathway [85]

Recent studies demonstrate that intestinal and hepatic transporters play compensatory roles in Mn excretion

Further, the inclusion of HIF while inhibiting GPX4 mitigates GPX4-mediated ferroptosis

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