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That is the short answer

Any sort of GI problem (including hormone imbalances like thyroid problems) may limit absorption

Some studies estimate that absorption may be as low as 1.3% from a 1000mcg dose, which is why you are likely to see supplements offering high doses

It is indicated for conditions such as pyridoxine deficiency from poor diet or malabsorption, anemia due to low B, and certain cases of neonatal seizures that respond to vitamin B therapy

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The rapid absorption and utilization of the vitamin can lead to noticeable improvements in energy and overall well-being