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Research from a 2023 article found significant mitochondrial structural and functional abnormalities in the muscle cells of long COVID patients, including: Disrupted cristae (mitochondrial) architecture Impaired electron transport chain function Reduced ATP production capacity These findings mirror what we see in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a condition that shares significant overlap with long COVID and is now thought to involve similar mitochondrial pathology