semaglutide vs placebo 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial PDF] Effect of Subcutaneous Semaglutide

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However, newer versions of these drugssuch as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)have been shown to significantly reduce both weight and hemoglobin A1c

The exact mechanism for weight reduction remains incompletely understood, though research suggests carbonic anhydrase inhibition and GABA potentiation may play roles

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Heres a look at how they stack up in a side-by-side comparison: Looking at this table, the difference is stark