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Most are missense mutations or mutations affecting pre-mRNA processing.64,128 Approximately one third of PFK-deficient patients are of Ashkenazi Jewish origin

However, scientific evidence demonstrating added weight loss benefit from combining the two is limited, and the primary mechanism driving weight loss in such a combination would still be semaglutide's GLP-1 activity

Experimental studies indicate that GLP-1 signaling can enhance genioglossus muscle tone, thereby reducing susceptibility to airway collapse during sleep (38, 39)

NCT04209543

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References Gonzalez-Ramirez, P