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(143) summed up GLP-1R agonists to treat obesity and prevent cardiovascular disease

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In cell-based functional assays, AMG 133 shows antagonist activity against human, cynomolgus monkey and rat GIPR (Fig

GLP-1R triggers various intracellular signaling pathways, such as the cAMP/PKA and PI3K/Akt pathways, by binding to endogenous GLP-1 or exogenous agonists, resulting in the enhancement of insulin secretion, inhibition of glucagon secretion, as well as anti-inflammatory and antioxidant stress response

Mol Metab

GLP-1RAs stimulate insulin secretion in a glucose-dependent manner, therefore, reduce the risk of hypoglycemia