General methodological considerations for the assessment of nutritional influences on human cognitive functions
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Early identification through testing is important, as insulin resistance is largely asymptomatic until complications develop
Critically, direct infusion of TNF- into the AI of normal-hearing mice induced tinnitus-like behavioral signs, providing causal evidence that microglial activation and TNF- signaling are sufficient to drive tinnitus pathophysiology (Wang et al., 2019)
J Exp Med (1993) 177(4):113543.10.1084/jem.177.4.1135 25 EngelMHoffmannTWagnerLWermannMHeiserUKiefersauerRet alThe crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism