Clinical Evidence on Semaglutide and Birth Control Safety Major clinical trials for semaglutide, including the SUSTAIN and SELECT trials, did not report contraceptive failure as a primary concern
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---Blenreps return highlights growing confidence in BCMA-targeted ADCs and signals a shift toward combination regimens that balance potency with manageable ocular toxicity reinforcing ADCs as a viable next pillar in MM therapy beyond CAR-T and bispecifics To view or add a comment, sign in Novo Nordisk has reported the mixed midphase results behind its push to enter a heart disease market served by Alnylam Pharmaceuticals, BridgeBio and Pfizer
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Mujdat Zeybel, MD, NIHR Nottingham Biomedical Research Centre This study demonstrated CMCS supplementation significantly decreased liver fat, improved liver function, and decreased liver inflammation in NAFLD patients, suggesting CMCS may be an effective therapeutic strategy for NAFLD, No drugs have been approved to treat NAFLD, and effective treatment options with long-term safety are urgently required. The combined metabolic cofactor supplementation (CMCS) regimen developed by the Nottingham group and used in this trial consists of: 1g nicotinamide riboside (NR), which raises mitochondrial NAD+ levels, and boosts fat metabolism 3.73g L-carnitine tartrate, which promotes transport of fat into the mitochondria 12.35g L-serine, which increases glutathione synthesis 2.55g N acetyl-L-cysteine (NAC), which also promotes glutathione production and reduces oxidative stress A total of 31 patients with MRI-confirmed non-alcoholic steatosis were randomized to either placebo (N=11) or the CMCS combination (N= 20)
