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The extracellular parts of TM1 and TM2 moved inward to the center, while TM7 moved outwards accompanied by conformational changes of ECL1

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The first line of defense against superoxide is the presence of a specific member of the family of metalloenzymes called superoxide dismutases (SODs), MnSOD or SOD2, specifically located in the mitochondrial matrix, which catalyzes the dismutation of superoxide anion into H 2 O 2 as shown in Figure 2

CagriSema: 20.4% vs semaglutide 14.9%