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In accordance with the 2018 NIA-AA Research Framework criteria [25] or the new 2023 NIA-AA revised criteria for AD [26], the incorporation of biomarkers is necessary in clinical practice

For the ones that make it to human trials, youre looking at another 5 to 7 years of clinical studies The unfortunate part of the literature is that whats often missing is all the failures, which would be even more informative than the successes. Alex The scientific literature itself is partially broken

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Patients with high-sensitivity variants often need slower dose escalation or lower starting doses to avoid nausea

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