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This DNA methylation is generated by a group of enzymes known as DNA methyltransferases (DNMTs) (Ducsay et al., de novo DNMTs (DNMT3a and DNMT3b) (Moore et al., Figure 2) (Yang et al., Figure 2 Histone modification by acetylation and deacetylation plays a central role in chromatin remodeling and epigenetic regulation

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In this way, LPS levels can be used as a marker of bacterial translocation, presumably indicating that there is a weakened intestinal barrier, which is related to chronic systemic inflammation and insulin resistance [116, 117]

This is why some people experience mild symptoms while others report more significant changes

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