The absence of early side effects does not by itself mean a medication is failing, and noticeable nausea is not proof that a medication is "working better." What may feel different during the first week
McLean BA, Wong CK, Campbell JE, Hodson DJ, Trapp S, Drucker DJ (2021) Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation
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Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis Diabetes
Staying well-hydrated, eating light and balanced meals, and avoiding heavy or greasy foods may help reduce early side effects like nausea
B.MacConellL.SarinV.TrautmannM.HerbertP