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Together, these findings indicate that activity of VTA dopamine neurons is significantly increased during cocaine seeking and that GLP-1R agonist pharmacotherapy prevents/blocks this cellular response and suppresses drug-seeking during withdrawal

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This discovery led to the development of pharmacologically stable GLP-1 receptor agonists for diabetes and obesity in the early 2000s

(PubMed) Canyelles M, Borras C, Rotllan N, Tondo M, Escola-Gil JC, Blanco-Vaca F

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