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Intellectual Property 20.1

Henry Lai, Norma Varela, PhD

Short half-life (~2 hours) Why dosing is built around clean pulses, not steady levels

30 Among the pathways activated by IR and IGF-1R signaling are the RASRAFMEK1/2extracellular signal-regulated kinase (ERK)-1/2 pathway 34 and the phosphatidylinositol-3-kinase (PI3K)AKTmammalian target of rapamycin (mTOR) pathway, two fundamental pathways for tumor cell proliferation and survival (Figure 2)

Palma R, Pronio A, Romeo M, Scognamiglio F, Ventriglia L, Ormando VM, et al