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Here are some groups at higher risk of deficiency: People with gastrointestinal issues: Conditions like pernicious anaemia, Crohns disease, or those who have undergone gastric bypass surgery can affect B12 absorption

But one, I dream of the day where after surgery, outside of just getting a nerve block and a couple days of painkillers, they prescribe the essential amino acids

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Constipation at higher doses Constipation becomes more common as your dose increases, particularly above 1.0 mg

Anti-inflammatory effects may appear within 1-3 days

This process temporarily increases local metabolic activity and can produce sensations of warmth, mild swelling, or heightened sensitivity to load