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[5] The Epithalon peptide was suggested to induce neuronal cell differentiation in retinal and periodontal ligament stem cells (hPDLSCs)

Long-term human safety has not been formally established

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Endometriosis symptoms often resolve during menopause and pregnancy and hormonal therapies are used to produce similar states to treat this condition (Winkel 2003)

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The dissection of the multiple mechanisms at the basis of c-MET pathway activation and primary and acquired resistance to c-MET inhibition in different tumor types will lead to further improvement in targeted drug development and patient selection to optimize outcome and toxicity exposure