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You lose a bunch of weight really fast, but maintaining is another thing,' he told People in 2022 about keep the weight off after the surgery

You need to take the tablet first thing in the morning on an empty stomach with no more than 4 ounces (120 mL) of plain water, then wait at least 30 minutes before eating, drinking anything else, or taking other medications

Anything less is a gamble

GLP-1 receptor agonists like semaglutide work by slowing stomach emptying, reducing hunger signals in the brain, and improving blood sugar control

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Understanding this timeline helps set appropriate expectations