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Thus, it is likely that various PARylating and MARylating enzymes are responsible for the decline in placental NAD + levels observed in this work

Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well (Kre et al., 2023), revealing a context-dependent interplay between CHAC1 and NRF2 that merits further study