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Of the two pharmacologic options, mannitol is more often used

Gallstonesan increasing problem: a study of hospital admissions in England between 1989/1990 and 1999/2000

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A multidisciplinary expert consensus published in Frontiers in Endocrinology recommends starting with osmotic laxatives (MiraLAX or magnesium) and only escalating to stimulant laxatives if osmotic options prove insufficient after 2-3 weeks of consistent use

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Artificially sweetened beverages like Coke Zero have been linked to other health issues, including: Increased risk of heart disease: An observational study found a link between artificially sweetened beverages and an increased risk of heart disease among women with no prior history of heart disease