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However, a comprehensive literature review revealed insufficient reliable data regarding the involvement of these RCD pathways in NAFLD/NASH

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[DOI] [PubMed] [Google Scholar] Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P

This is likely due to structural differences: ipamorelin Aib/D-2-Nal backbone produces a different binding mode at GHS-R1a that may favor specific downstream signaling pathways (biased agonism) compared to the His/D-Trp backbone of GHRP-6

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