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Malekshah and colleagues then armed AD-MSCs with secreted carboxylesterase-2, allowing systemic irinotecan to be converted into its potent metabolite SN-38 directly inside intraperitoneal metastases

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In ferroptosis response, macrophage Toll-like receptor 2 (TLR2) initially interacts with oxidized phospholipid peroxides and 1-stearoyl-2-15-hPEtE-sn-glycero-3-phosphatidyl-ethanolamine (SAPE-OOH) on ferroptosis cell surfaces, enhancing macrophage phagocytosis efficiency