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Tracking this over time, alongside protein intake and training volume, gives you the data to adjust your protocol before significant lean mass loss occurs rather than after

Essentially, your body becomes more efficient at using fewer calories, known as metabolic adaptation

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Tirzepatide lacks glucagon receptor activation, so split dosing preserves more of its efficacy

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The results in humans, however, were modest enough that it has not advanced to Phase 3 approval for any fat loss indication