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A pilot study subsequently conducted by Holst in collaboration with Mette Zander at Hvidovre Hospital between September 1999 and October 2000 indicated that continuous subcutaneous infusions of synthetic GLP-1 over 6 weeks into patients with quite severe type 2 diabetes dramatically improved their blood sugar control, lowered glycated haemoglobin levels and decreased their body weight

Back Drucker, DJ, Mojsov, S, Habener, JF (25 July 1986) 'Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene', Journal Biological Chemistry , 261/21, 9637-43

doi: 10.1001/jama.2024.6586

doi:10.1038/s41392-024-01951-9 Uusitupa M, Khan TA, Viguiliouk E, et al

Theres also been a spike in adverse reactions to compounded GLP-1s that the FDA suspects is due to accidental overdosing

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