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Combine it with retinoids at pH 5.5 to 6.5 and the copper complex begins to dissociate

Commonly reported reactions in human studies are generally mild to moderate gastrointestinal issues, including nausea, vomiting, and diarrhea

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The chemical structure of caffeine contains a purine ring, which chemically resembles adenosine and is a natural non-selective receptor antagonist of adenosine (Figure 1) (Eltzschig et al., 2012)

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