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Because Asn does not actively accumulate in the brain due to the blood-brain barrier, reduced activity of ASNS in the brain is thought to contribute to the disease

Degraded -carrageenan activates NF-kB and AP-1 pathways in macrophages and enhances LPS-induced TNF- secretion through AP-1

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A D_M 3.3 between generic and RLD batches establishes statistical sameness of the HOS