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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

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Science makes the distinction clearwhile GLP-1 therapies can help begin the journey, surgery often provides the enduring reset the body needs for long-term metabolic health and stability

Endocrinology (2008) 149(3):133849

The prevalence of this condition has nearly tripled in the time span between 1975 and 2016